Drive away from Soho (4)
I believe the answer is:
shoo
'drive away' is the definition.
(shooing is a kind of driving away)
'from soho' is the wordplay.
'from' indicates an anagram (from the letters).
'soho' anagrammed gives 'SHOO'.
(Other definitions for shoo that I've seen before include "Expression to chase away an animal" , "Get away" , "Sound uttered to make animals go away" , "Go away quickly!" , "told to go away!" .)