Droop when left with misery (8)
I believe the answer is:
languish
'droop' is the definition.
(thesaurus)
'left with misery' is the wordplay.
'left' becomes 'l' (common abbreviation).
'with' says to put letters next to each other.
'misery' becomes 'anguish' (I've seen this before).
'l'+'anguish'='LANGUISH'
'when' is the link.
(Other definitions for languish that I've seen before include "Suffer neglect" , "Lose or lack vitality" , "Pine, waste away" , "Grow weak or feeble" , "Long" .)