Drove female mad at last (4)
I believe the answer is:
herd
'drove' is the definition.
(I've seen this before)
'female mad at last' is the wordplay.
'female' becomes 'her' (I've seen this before**).
'at last' says to take the final letters.
The last letter of 'mad' is 'd'.
'her'+'d'='HERD'
(Other definitions for herd that I've seen before include "Collection of cattle" , "A collection of livestock" , "Assemblage" , "Drive" , "Group of, eg, cows" .)