Editor off, she'll recast novel (4,2,3,5)
I believe the answer is:
lord of the flies
'novel' is the definition.
(I've seen this before)
'editor off she'll recast' is the wordplay.
'recast' indicates an anagram.
'editor'+'off'+'shell'='editoroffshell'
'editoroffshell' with letters rearranged gives 'LORD OF THE FLIES'.
(Other definitions for lord of the flies that I've seen before include "peer: he clocks up the air miles?" , "Novel" .)