Empty garage next to little house (6)
I believe the answer is:
gemini
'house' is the definition.
(each star sign has an astrological house)
'empty garage next to little' is the wordplay.
'empty' suggests removing the centre.
'next to' is a charade indicator (letters next to each other).
'little' becomes 'mini'.
'garage' with its middle taken out is 'ge'.
'ge'+'mini'='GEMINI'
(Other definitions for gemini that I've seen before include "star group" , "Zodiac sign - the Twins" , "House" , "Twins constellation" , "lot of stars" .)