Endure nasty virus very close to home (7)
I believe the answer is:
survive
'endure' is the definition.
('survive' can be a synonym of 'endure')
'nasty virus very close to home' is the wordplay.
'nasty' indicates anagramming the letters.
'very' becomes 'v' (abbreviation).
'close to' suggests the final letters (the close/ending of).
The final letter of 'home' is 'e'.
'virus' anagrammed gives 'survi'.
'survi'+'v'+'e'='SURVIVE'
(Other definitions for survive that I've seen before include "Endure or last" , "Outlast" , "Continue to exist" , "Remain alive" , "Live on" .)