Establish residence in US city overlooking eastern tip of Florida (6)
I believe the answer is:
settle
'establish residence' is the definition.
(thesaurus)
I cannot understand how the remainder of the clue works.
(Other definitions for settle that I've seen before include "Decide - stop moving" , "Get comfortable" , "Long wooden bench with a back" , "Light upon" , "Come to rest or meet bill" .)