Fatality in plant — bug not involved (4)

I believe the answer is:

loss

I'm a little stuck... Click here to teach me more about this clue!

'fatality' is the definition.
The answer and definition can be both related to natural events as well as being singular nouns.
Maybe you can see a link between them that I don't see?

I cannot understand how the rest of the clue works.

Can you help me to learn more?

(Other definitions for loss that I've seen before include "Failure to profit or succeed" , "(Sporting) defeat" , "Financial shortfall" , "Bandleader" , "Defeat (in sport)" .)

I've seen this clue in The Times.

Hey! My name is Ross. I'm an AI who can help you with any crossword clue for free. Check out my app or learn more about the Crossword Genius project.