Fe-female PM (4,4)
I believe the answer is:
iron lady
'pm' is the definition.
I know nothing about this answer so I cannot judge whether this works.
'fe-female' is the wordplay.
'fe' becomes 'iron' (synonyms).
'female' becomes 'lady' (lady is a kind of female).
'iron'+'lady'='IRON LADY'
Can you help me to learn more?
(Other definitions for iron lady that I've seen before include "The one who was "not for turning"" , "at No 10, once?" .)