Fed up with idle artists regularly turning back (5)
I believe the answer is:
tired
'fed up' is the definition.
(thesaurus)
'idle artists regularly turning back' is the wordplay.
'regularly' means one should take alternating letters (regularly take one letter, leave next etc.).
'turning back' says the letters should be written in reverse.
'idle'+'artists'='idleartists'
The alternating letters of 'idleartists' are 'derit'.
'derit' reversed gives 'TIRED'.
'with' acts as a link.
(Other definitions for tired that I've seen before include "getting bored" , "Zonked" , "Spent" , "Physically or mental weary" , "Played out" .)