Feel agitated and run away (4)
I believe the answer is:
flee
'run away' is the definition.
(thesaurus)
'feel agitated' is the wordplay.
'agitated' indicates anagramming the letters.
'feel' anagrammed gives 'FLEE'.
'and' is the link.
(Other definitions for flee that I've seen before include "retreat" , "Run quickly away" , "Do a runner" , "Leave" , "Take to one's heels" .)