Female, one having to live in the home (8)
I believe the answer is:
fireside
'in the home' is the definition.
(I've seen this before)
'female one having to live' is the wordplay.
'female' becomes 'f' (abbreviation).
'one' becomes 'i' (Roman numeral).
'having' is a charade indicator (letters next to each other).
'to live' becomes 'reside' (residing is a kind of living).
'f'+'i'+'reside'='FIRESIDE'
(Other definitions for fireside that I've seen before include "somewhere cosy" , "Comfy place for chair" , "warm, cosy place" , "One warmed by this" , "Warm domestic spot" .)