Filled with bit of ire, go off and scream (4)
I believe the answer is:
riot
'scream' is the definition.
(synonyms)
'filled with bit of ire go off' is the wordplay.
'filled with' means one lot of letters goes inside another.
'bit of' indicates taking the first letters.
'go off' becomes 'rot' (as in food going off).
The initial letter of 'ire' is 'i'.
'i' put into 'rot' is 'RIOT'.
'and' is the link.
(Other definitions for riot that I've seen before include "Civil disorder" , "Uproar" , "loose living" , "Disturbance by unruly mob" , "Violent disturnance of the peace (by crowd)" .)