Film setter barking by barrier (4,6)
I believe the answer is:
wall street
'film' is the definition.
(1987 film)
'setter barking by barrier' is the wordplay.
'barking' indicates anagramming the letters (UK slang for mad).
'by' means one lot of letters go next to another.
'barrier' becomes 'wall' (a wall acts as a barrier).
'setter' anagrammed gives 'street'.
'street' put after 'wall' is 'WALL STREET'.
(Other definitions for wall street that I've seen before include "business centre" , "Financial hub" , "part of Manhattan" , "US financial area" , "Location of US stock exchange" .)