Firm with graduate in a stupor (4)
I believe the answer is:
coma
'a stupor' is the definition.
(I've seen this before)
'firm with graduate' is the wordplay.
'firm' becomes 'co' (a firm is a company).
'with' means one lot of letters go next to another.
'graduate' becomes 'ma' (abbreviation for Master of Arts).
'co'+'ma'='COMA'
'in' acts as a link.
(Other definitions for coma that I've seen before include "Deep trance" , "State of insensibility" , "State of deep (often prolonged) unconsciousness" , "Unconscious state" , "Unconsciousness from which person cannot be aroused" .)