Fold of skin initially described expertly with love and patience (6)
I believe the answer is:
dewlap
'fold of skin' is the definition.
(I've seen this before)
'initially described expertly with love and patience' is the wordplay.
'initially' says to take the initial letters.
The first letters of 'described expertly with love and patience' is 'DEWLAP'.
(Other definitions for dewlap that I've seen before include "drooping throat" , "Fold hanging beneath animal's throat" , "Fold of skin hanging from throat of cattle" , "Loose skin below an animal's throat" , "Throat's loose skin" .)