For each spirit, a bubbly knocked back: no sweat (12)
I believe the answer is:
perspiration
'sweat' is the definition.
(I know that sweat can be written as perspiration)
'for each spirit a bubbly knocked back no' is the wordplay.
'for each' becomes 'per' (I've seen this before).
'bubbly' is an anagram indicator.
'knocked back' is a reversal indicator.
'no' back-to-front is 'on'.
'spirit'+'a'='spirita'
'spirita' with letters rearranged gives 'spirati'.
'per'+'spirati'+'on'='PERSPIRATION'
(Other definitions for perspiration that I've seen before include "is exuded" , "Ninety nine percent of genius" , "Sweat" .)