For example, initially he or she (6)
I believe the answer is:
female
'she' is the definition.
(I've seen this in another clue)
'for example initially he' is the wordplay.
'initially' says to take the initial letters.
'he' becomes 'male' (I can't explain this - if you can you should believe this answer much more).
The initial letters of 'for example' is 'fe'.
'fe'+'male'='FEMALE'
'or' acts as a link.
Can you help me to learn more?
(Other definitions for female that I've seen before include "Able to bear offspring" , "A gender" , "On the distaff side" , "Woman or girl" , "That's what she is" .)