Frail men tend to catch illness (7)
I believe the answer is:
ailment
'illness' is the definition.
(an ailment is an illness or health problem)
'frail men tend to catch' is the wordplay.
'to catch' indicates the answer is hidden within the clue (the answer is caught in the letters of the clue).
'AILMENT' is hidden in the letters of 'frail men tend'.
(Other definitions for ailment that I've seen before include "Bodily disorder or disease" , "Physical disorder" , "Malady" , "Slight but persistent illness" , "infirmity" .)