Game among some brings pain (5)
I believe the answer is:
agony
'pain' is the definition.
(agony is a kind of pain)
'game among some' is the wordplay.
'game' becomes 'go' (go is a kind of game).
'among' means one lot of letters goes inside another.
'some' becomes 'any' ('any' can be similar in meaning to 'some').
'go' inserted into 'any' is 'AGONY'.
'brings' acts as a link.
(Other definitions for agony that I've seen before include "Suffering - anguish" , "Distress" , "Great pain or suffering" , "woe" , "This aunt answers readers' questions" .)