Game babe's playing with everyone (8)
I believe the answer is:
baseball
'game' is the definition.
(baseball is a kind of game)
'babe's playing with everyone' is the wordplay.
'playing' is an anagram indicator.
'with' is a charade indicator (letters next to each other).
'everyone' becomes 'all' (all people).
'babes' is an anagram of 'baseb'.
'baseb'+'all'='BASEBALL'
(Other definitions for baseball that I've seen before include "Game played in the strange sable lab" , "US/Canadian game" , "Lea blabs about the sport" , "American team game" , "Summer sport of US" .)