Game of patience? (3)
I believe the answer is:
tie
'game' is the definition.
(I've seen this before)
'of patience?' is the wordplay.
'of' indicates a hidden word.
'TIE' is hidden within 'patience'.
(Other definitions for tie that I've seen before include "Almost level" , "may make one hot under the collar" , "Neck-cloth" , "Lace" , "11 [KNOT]" .)