Generous drink's raised spirits essentially (5)
I believe the answer is:
'generous' is the definition.
(similar in meaning)
'drink's raised spirits essentially' is the wordplay.
'drink's raised' becomes 'lar' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'spirits' becomes 'angels' (I've seen this before).
'essentially' says to take the centre.
The middle letters of 'angels' are 'ge'.
Can you help me to learn more?
(Other definitions for large that I've seen before include "Lake" , "Titanic" , "Regal (anag)" , "broad" , "Lager (anag.)" .)