Girl leads off with Frenchman (6)
I believe the answer is:
damsel
'girl' is the definition.
(I know that damsel is a type of maid)
'leads off with frenchman' is the wordplay.
'off with' is an anagram indicator.
'frenchman' becomes 'm' (abbreviation for Monsieur - like 'Mr').
'leads' mixed up with 'm' gives 'DAMSEL'.
(Other definitions for damsel that I've seen before include "(Poetically) a young unmarried woman" , "Young woman (archaic)" , "Old-fashioned young woman" , "Girl (literary)" , "Young lady of old, perhaps in distress" .)