Girls regularly hosted by party animals in residence (8)
I believe the answer is:
domicile
'residence' is the definition.
(I've seen this before)
'girls regularly hosted by party animals' is the wordplay.
'regularly' indicates alternate letters (regularly take one letter, leave next etc.).
'hosted by' is an insertion indicator.
'party' becomes 'do' (do is a kind of party).
'animals' becomes 'mice' (mouse is a kind of animal).
The alternate letters of 'girls' are 'il'.
'do'+'mice'='domice'
'il' going into 'domice' is 'DOMICILE'.
'in' acts as a link.
(Other definitions for domicile that I've seen before include "Permanent legal residence" , "Place of residence, abode" , "One's permanent residence" , "A person's principal home" , "Dwelling" .)