Give up drugs with cocaine cut (6)
I believe the answer is:
eschew
'give up' is the definition.
(I've seen this before)
'drugs with cocaine cut' is the wordplay.
'drugs' becomes 'es' (E is a term for an ecstasy pill).
'with' says to put letters next to each other.
'cocaine' becomes 'c' (drugs abbreviation).
'cut' becomes 'hew' (I've seen this before**).
'es'+'c'+'hew'='ESCHEW'
(Other definitions for eschew that I've seen before include "Deliberately stay away from" , "Avoid or abstain from, action or food" , "'Avoid, stay away from (6)'" , "Deliberately stay clear of" , "Ignore" .)