Give up the burden (7)
I believe the answer is:
refrain
This clue is a double definition.
'give up' is the first definition.
(thesaurus)
'the burden' is the second definition.
(I've seen this before)
(Other definitions for refrain that I've seen before include "burden" , "tune" , "Forbear from chorus?" , "Do without" , "Repeating line in a song, poem" .)