Go wrong with everything running right originally (3)
I believe the answer is:
err
'go wrong' is the definition.
(I've seen this before)
'everything running right originally' is the wordplay.
'originally' indicates taking the first letters.
The first letters of 'everything running right' is 'ERR'.
'with' acts as a link.
(Other definitions for err that I've seen before include "Stray from the straight and narrow" , "Blunder" , "Slip up" , "Bungle" , "Leave the straight and narrow" .)