Grave case of unusual herpes spread around college (9)
I believe the answer is:
sepulchre
'grave' is the definition.
(I know that sepulchre is a type of grave)
'case of unusual herpes spread around college' is the wordplay.
'case of' suggests removing the centre (like emptying a case).
'spread' indicates anagramming the letters.
'around' is an insertion indicator.
'college' becomes 'c'.
'unusual' with its centre taken out is 'ul'.
'ul'+'herpes'='ulherpes'
'ulherpes' with letters rearranged gives 'sepulhre'.
'sepulhre' enclosing 'c' is 'SEPULCHRE'.
(Other definitions for sepulchre that I've seen before include "Help curse (anag) - tomb" , "Helps cure (anag)" , "vault" , "Burial chamber" , "Resting place" .)