Guide a soothsayer round the West End (5)
I believe the answer is:
steer
'guide' is the definition.
(I know that guide can be written as steer)
'a soothsayer round the west end' is the wordplay.
'a soothsayer' becomes 'seer' (I've seen this in another clue).
'round' indicates putting letters inside.
'end' suggests the final letters.
The last letter of 'west' is 't'.
'seer' going around 't' is 'STEER'.
(Other definitions for steer that I've seen before include "Handle" , "member of herd" , "Exercise control" , "Con" , "Direct; young ox" .)