Hand on new deposit (4)
I believe the answer is:
pawn
'deposit' is the definition.
(thesaurus)
'hand on new' is the wordplay.
'hand' becomes 'paw' ('paw' can be a synonym of 'hand').
'on' means one lot of letters go next to another.
'new' becomes 'n'.
'paw'+'n'='PAWN'
(Other definitions for pawn that I've seen before include "Lend uncle" , "Give as security" , "Exploited person" , "Insignificant player" , "One getting used" .)