Sadly mean to grasp silver and run (6)
I believe the answer is:
manage
'run' is the definition.
(thesaurus)
'sadly mean to grasp silver' is the wordplay.
'sadly' indicates an anagram.
'to grasp' means one lot of letters goes inside another.
'silver' becomes 'ag' (Ag is the chemical symbol for silver).
'mean' anagrammed gives 'mane'.
'mane' enclosing 'ag' is 'MANAGE'.
'and' is the link.
(Other definitions for manage that I've seen before include "Control; cope" , "Exercise control - don't fail" , "Handle, oversee" , "Run, administer" , "get on" .)