Handicap (12)
'handicap' is the definition.
(I know that handicap has the is a more specific form of the action disadvantage)
This is the entire clue.
(Other definitions for disadvantage that I've seen before include "Flaw -- weak point" , "Hindrance" , "Downside" , "Catch" , "Drawback" .)
(Other definitions for debility that I've seen before include "Weakness (of body)" , "Feebleness, frailty" , "Weakness (from illness)" .)
'handicap' is the definition.
(I know that handicap can be written as hindrance)
This is the entire clue.
(Other definitions for hindrance that I've seen before include "Chain nerd up - it delays progress" , "Something that holds back" , "Nicer hand (anag.)" , "Obstacle" , "Obstruction" .)