Happens not to be the thing tinned? The opposite (4)
I believe the answer is:
isnt
'happens not' is the definition.
(is not)
I cannot understand how the remainder of the clue works.
(Other definitions for isnt that I've seen before include "Ain't" , "Does not happen to be" , "denial?" , "Is not (colloq.)" , "In the present, not to be" .)