He dropped with a cry of pain (6)
I believe the answer is:
fellow
'he' is the definition.
(thesaurus)
'dropped with a cry of pain' is the wordplay.
'dropped' becomes 'fell' (I've seen this in another clue).
'with' means one lot of letters go next to another.
'a cry of pain' becomes 'ow' (exclamation of pain).
'fell'+'ow'='FELLOW'
(Other definitions for fellow that I've seen before include "Companion or associate" , "Relating to a person in the same situation as oneself" , "Senior member of a college or university" , "Boy or man" , "college type" .)