He is out of the pram, prepared to walk (5)
I believe the answer is:
tramp
'to walk' is the definition.
(tramp can mean to walk around)
'he is out of the pram prepared' is the wordplay.
'is out of' indicates named letters should be taken away ('out of' can mean no longer having).
'prepared' indicates an anagram.
'the' with 'he' taken away is 't'.
'pram' anagrammed gives 'ramp'.
't'+'ramp'='TRAMP'
(Other definitions for tramp that I've seen before include "Bum!" , "Live as a vagrant" , "Walk noisily; vagrant" , "man down on his luck" , "Itinerant" .)