Hold in high regard, in particular (7)
I believe the answer is:
respect
This clue is a triple definition!
'hold in high regard' is the first definition.
(I've seen this before)
'in' is the second definition.
(thesaurus)
'particular' is the third definition.
(respect is a kind of particular)
(Other definitions for respect that I've seen before include "Comply with - deference" , "Feeling of deep admiration" , "Admiration or esteem" , "Pay attention to" , "Deference, obedience" .)