Hold items and run after vehicle (5)
I believe the answer is:
cargo
'hold items' is the definition.
(I've seen this in another clue)
'run after vehicle' is the wordplay.
'run' becomes 'go' (both can mean to function or work).
'after' is a charade indicator (letters next to each other).
'vehicle' becomes 'car' (car is a kind of vehicle).
'go' after 'car' is 'CARGO'.
'and' is the link.
(Other definitions for cargo that I've seen before include "Payload" , "Shipment" , "Stuff on board" , "Goods carried by a large vehicle" , "Baggage" .)