Hold items and run after vehicle (5)
I believe the answer is:
cargo
'hold items' is the definition.
(I've seen this in another clue)
'run after vehicle' is the wordplay.
'run' becomes 'go' (both can mean to function or work).
'after' means one lot of letters go next to another.
'vehicle' becomes 'car' (car is a kind of vehicle).
'go' after 'car' is 'CARGO'.
'and' acts as a link.
(Other definitions for cargo that I've seen before include "Payload" , "Shipment" , "Stuff on board" , "Goods carried by a large vehicle" , "Baggage" .)