Home again, father (5)
I believe the answer is:
padre
'father' is the definition.
(I know that father can be written as Padre)
'home again' is the wordplay.
'home' becomes 'pad' (pad can mean a person's home).
'again' becomes 're' (prefix meaning 'again').
'pad'+'re'='PADRE'
(Other definitions for padre that I've seen before include "Military chaplain" , "Father" , "Army chaplain" , "Army serviceman?" , "clerical worker" .)