Hotel in reach in poor quarter (6)
I believe the answer is:
ghetto
'poor quarter' is the definition.
(I've seen this before)
'hotel in reach' is the wordplay.
'hotel' becomes 'h' (phonetic alphabet: alpha, bravo, charlie etc.).
'in' means one lot of letters goes inside another.
'reach' becomes 'getto' (getting to is a kind of reaching**).
'h' going within 'getto' is 'GHETTO'.
'in' is the link.
(Other definitions for ghetto that I've seen before include "City quarter to which Jewish people were confined" , "Area for those deprived" , "Slum area occupied by particular group" , "A poor quarter of a city" , "Run-down area" .)