Humiliation has me upset (5)
I believe the answer is:
shame
'humiliation' is the definition.
(I've seen this in another clue)
'has me upset' is the wordplay.
'upset' is an anagram indicator.
'has'+'me'='hasme'
'hasme' is an anagram of 'SHAME'.
(Other definitions for shame that I've seen before include "pity!" , "scandal" , "Ignomony" , "Humiliation; dishonour" , "disgraceful" .)