Immorality from John with senses defective (9)
I believe the answer is:
looseness
'immorality' is the definition.
(I've seen this before)
'john with senses defective' is the wordplay.
'john' becomes 'loo' (loo is a kind of john).
'with' says to put letters next to each other.
'defective' indicates anagramming the letters.
'senses' is an anagram of 'seness'.
'loo'+'seness'='LOOSENESS'
'from' acts as a link.
(Other definitions for looseness that I've seen before include "immorality" , "Inexactitude" , "A lack of strictness" .)