In Indiana, the maniacal curse (8)
I believe the answer is:
anathema
'curse' is the definition.
(anathema can mean a curse)
'in indiana the maniacal' is the wordplay.
'in' says the answer is hidden in the clue.
'ANATHEMA' is hidden within 'indiana the maniacal'.
(Other definitions for anathema that I've seen before include "One detested, cursed" , "Someone or something that is detested" , "Object of detestation" , "thing we detest" , "Religious curse" .)