In operation (2,3,7)
(Other definitions for up and running that I've seen before include "working properly" , "Fully functional" , "Already active" , "like a jogger first thing?" , "like the early morning athlete" .)
'in operation' is the definition.
(I've seen this before)
This is the entire clue.
(Other definitions for active that I've seen before include "Engaged, not idle" , "Busy, energetic" , "In actual operation" , "Mobile" , "Moving about, functioning" .)
'in operation' is the definition.
(I've seen this before)
This is the entire clue.
(Other definitions for running that I've seen before include "White City event" , "cross-country event?" , "Managing (a company)" , "Moving fast, on track perhaps" , "Managing; flowing" .)