In plays, the cast can vary (4)
I believe the answer is:
acts
'in plays' is the definition.
'acts' can be an answer for 'plays' ('act' can be a synonym of 'play'). I'm not sure about the 'in' bit.
'cast can vary' is the wordplay.
'cast' anagrams to 'ACTS'.
But, I am unsure how this is indicated.
'the' acts as a link.
Can you help me to learn more?
(Other definitions for acts that I've seen before include "performers for revue, say?" , "[BOOK] of the 26 [BIBLE]" , "Parliaments pass them" , "bands, comedians, etc" , "Deeds; NT book" .)