Indisposed star can't perform (8)
I believe the answer is:
transact
'perform' is the definition.
(thesaurus)
'indisposed star can't' is the wordplay.
'indisposed' indicates anagramming the letters.
'star'+'cant'='starcant'
'starcant' is an anagram of 'TRANSACT'.
(Other definitions for transact that I've seen before include "Conduct trade" , "Buy or sell" , "Manage" , "Conduct business, negotiate" , "Carry out, like business" .)