Inert gas combusts, most hot (8)
I believe the answer is:
angriest
'most hot' is the definition.
'inert gas combusts' is the wordplay.
'combusts' indicates an anagram.
'inert'+'gas'='inertgas'
'inertgas' with letters rearranged gives 'ANGRIEST'.
(Other definitions for angriest that I've seen before include "Most irate and furious" , "Most annoyed or hostile" , "Extremely mad" , "Most characteristic of 1950s young men" , "Most wrathful" .)