Insight from wife is initially devoid of meaning (6)
I believe the answer is:
wisdom
'insight' is the definition.
(thesaurus)
'wife is initially devoid of meaning' is the wordplay.
'wife' becomes 'w' (abbreviation).
'initially' indicates taking the first letters.
The first letters of 'devoid of meaning' is 'dom'.
'w'+'is'+'dom'='WISDOM'
'from' acts as a link.
(Other definitions for wisdom that I've seen before include "Some say it's a combination of experience, knowledge and good judgment" , "Accumulated experience and mature judgement" , "Type of tooth" , "See 13" , "Knowledge coupled with good judgement" .)