Insinuation affected nurse following house party (8)
I believe the answer is:
innuendo
'insinuation' is the definition.
(I know that insinuation can be written as innuendo)
'affected nurse following house party' is the wordplay.
I cannot quite understand how this works, but
'nurse' could be 'en' (abbreviation for enrolled nurse) and 'en' is present in the answer.
'party' could be 'do' (do is a kind of party) and 'do' is located in the answer.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for innuendo that I've seen before include "An unpleasant insinuation or intimation" , "Oblique allusion" , "Indirect implication" , "An unpleasant allusion or insinuation" , "Malicious suggestion" .)