Intoxicated with a noted game of chance (6)
I believe the answer is:
blotto
'intoxicated' is the definition.
(similar in meaning)
'with a noted game of chance' is the wordplay.
'with' is a charade indicator (letters next to each other).
'a noted' becomes 'b' (I can't justify this - if you can you should give a lot more credence to this answer).
'game of chance' becomes 'lotto' (I've seen this in another clue).
'b'+'lotto' is 'BLOTTO'.
Can you help me to learn more?
(Other definitions for blotto that I've seen before include "Helplessly drunk (slang)" , "Tight" , "Wasted" , "Get very drunk" , "To bolt away in drunk state" .)